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2010 Changes in serum and synovial fluid biomarkers after acute injury Open Access
Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand the early biological changes which occur after acute injury, we investigated synovial fluid and serum biomarkers.
These data strongly suggest that the biology after acute injury reflects that seen in cartilage explant models stimulated with pro-inflammatory cytokines, which are characterized by an initial wave of proteoglycan loss followed by subsequent collagen loss. As the rise of collagen biomarkers in synovial fluid occurs within the first month after injury, and as collagen loss is thought to be irreversible, very early treatment with agents to either reduce inflammation and/or reduce collagen loss may have the potential to reduce the onset of future post-traumatic osteoarthritis.
Catterall JB, Stabler TS, Flannery CR, Kraus VB: Changes in serum and synovial fluid biomarkers after acute injury.
Arthritis Res Ther 2010, 12:R229 (Full text)
Type: Reference Material
Author/Contact: Catterall et al
Institution: Arthritis Research & Therapy
Submitted by: admin
Added: Fri Apr 29 2011
Last Modified: Tue May 31 2011