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Hypoparathyroidism eMedicine Pediatrics
Hypoparathyroidism results from defective synthesis or secretion of parathyroid hormone (PTH), end-organ resistance, or inappropriate regulations that result from the activated or antibody-stimulated calcium-sensing receptor (CaSR).1 These defects can be inherited or acquired. PTH secretion by the parathyroid glands (prime regulators of serum calcium concentration) maintains serum calcium within a strict range. Biochemical hallmarks of hypoparathyroidism include hypocalcemia and hyperphosphatemia. Severe hypocalcemia presents with seizures, stridor, prolonged QTc, and tetany.
James CM Chan, MD Updated: Sep 17, 2009
Type: Reference Material
Submitted by: admin
Added: Sun Dec 06 2009