Previous | Next
Paget Disease Bone Scan MedPix Topic 4755
Contributor: Christopher J Bennett - National Capital Consortium
Paget's disease at osseous scintigraphy
Factoid 4755 - Created: 2003-04-24 12:50:56-04 - Modified: 2003-05-04 19:15:37-04
ACR Codes: 4.5
Pagetâ€™s disease is characterized by high rates of bone turnover and the formation of abnormal, weak bone. It is extremely common, found in approximately 10% of patients over 80 years of age. Classically, the course of Pagetâ€™s disease can be divided into lytic, mixed, and blastic phases, but in reality a continuum of pathologic changes are present. The pelvis, spine, skull and proximal long bones are frequently affected. Patients are often asymptomatic, but pain, fracture, bowing deformity and a variety of other complications occur. Sarcomatous degeneration (to osteosarcoma, chondrosarcoma, or malignant fibrous histiocytoma/fibrosarcoma) is thought to occur in 1% of cases.
Expansion of bone, cortical thickening, and coarsened trabeculae are the radiographic hallmarks. Osseous scintigraphy is useful to define polyostotic disease. Intense uptake is seen in affected bones, but expansion may be difficult to appreciate. In quiescent disease, uptake may be minimal even if radiographic changes are pronounced.
Type: Reference Material
Author/Contact: Christopher Bennett
Submitted by: admin
Added: Fri Mar 30 2007
Last Modified: Tue Jul 21 2009