Pagets Disease of Bone Information Diseases Database

Description: Paget's disease of bone aka/or Osteitis deformans may cause or feature Miscellaneous syndromes Carcinogenesis Osteoporosis Pathological fracture Symptoms and Signs Angioid streaks Arthropathy Back pain Bone pain Conductive hearing loss Facies abnormality Genu varum Hypertension, systemic Kyphosis Peripheral neuropathy Sabre tibia Sensorineural hearing loss Skull bossing Biochemical abnormalities Acid phosphatase levels raised (plasma or serum) Alkaline phosphatase bone isoenzyme levels raised (plasma or serum) Hypercalciuria X-ray abnormalities Osteosclerosis Cardiac and vascular conditions Cardiac failure, high output Inflammatory conditions Osteitis may be a risk factor for osteosarcoma Paget's disease of bone: Definition(s) via UMLS Osteitis Deformans: "A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry." Source: Medical Subject Headings, 2007_2006_08_08 Osteitis Deformans: "disease marked by repeated episodes of increased bone resorption followed by excessive repair, resulting in weakened, deformed bones of increased mass." Source: CRISP Thesaurus, 2006 Osteitis Deformans: "Paget's Disease is a disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. (On-line Medical Dictionary)" Source: National Cancer Institute Thesaurus, 2006_03D