Adamantinoma Wheeless

Description: - rare tumor of unknown origin; - occurs primarily in young males between 10 - 30 years of age (most common after skeletal maturity); - pts present w/ firm, slowly enlarging mass that produces minimal disability; - on other occassions the presenting features will be pain, swelling or pathologic fracture; - sites of involvement: - mandible or tibial diaphysis is involved in 90% of pts; - occassionally tumor arises in forearm, hands, or feet; - histology: - multiple biopsies may be required to have an representative sample; - look for a biphasic pattern of glandular epithelial cells which are surrounded by fibrous spindle cells;