Osteopoikilosis MedPix

Description: Enostoses (bone islands) form when endochondral ossification proceeds normally, but the mature bony trabeculae fail to properly remodel. Osteopoikilosis (osteopathia condensans disseminata, or “spotted bone disease”), like enostosis or osteopathia striata, is typically an autosomal dominant, asymptomatic disorder characterized by an abnormality in the endochondral bone maturation process. Osteopoikilosis results in numerous rounded or oval, 2-10mm enostoses that appear in childhood and persist throughout life.