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Fibrous Dysplasia AAOS

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Location: http://orthoinfo.aaos.org/fact/thr_report.cfm?Thread_ID=485&topcategory=Tumors

Description: Description Fibrous dysplasia is a chronic condition of the skeleton where a portion of a bone develops abnormally. The condition begins before birth. It is caused by a gene mutation that affects the cells that produce bone. The mutation causes the cells to form an abnormal type of fibrous bone that gradually grows and expands over a period of years, causing a weakened area of the bone. The area of weak bone can cause pain. It can crack (fracture) the bone, and may lead to deformity. Although the abnormal bone forms before birth, its presence is often not discovered until childhood, adolescence, or even adulthood. Any bone may be affected-the most common bones involved are the thighbone, shinbone, ribs, skull, upper arm bone and pelvis. Usually only one bone is involved (monostotic fibrous dysplasia). Less often, multiple bones are involved (polyostotic fibrous dysplasia). The polyostotic form is generally more severe and is discovered earlier. This form can involve as few as two bones in the same limb or multiple bones throughout the skeleton.

Type: Reference Material
Author/Contact: Not available
Institution: AAOS
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Language: English

Submitted by: admin
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Added: Sat Dec 09 2006