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Giant Cell Tumor Wikibooks
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Giant cell tumors of the bone are uncommon bone tumors which represent around 4-5% of primary bone tumors and 18% of all benign bone lesions. They are interesting in the fact that their classic radiographic appearance is easily identifiable.
Giant cell tumors can either be benign or malignant, although the majority of them are benign. Radiographically, benign versus malignant tumors are difficult to distinguish. In most patients, the tumor has an indolent course, but repeated local recurrence of the tumor does happen. Approximately 5% of giant cell tumors are defined as malignant. Malignancy usually occurs as the result of malignant transformation after radiation therapy.
These tumors are slightly more common in females, with 50-57% of cases occurring in females. The general age range for giant cell tumors is 20-40 years old. Approximately 85% of tumors occur in the long bones, namely the distal femur, proximal tibia, proximal humerus, and distal radius. Another location typical of giant cell tumor is the spine, particularly the sacrum. Spinal involvement is typically in the vertebral body, although its location is variable.
Clinical presentation is nonspecific, and it usually is pain at the tumor site. Pathologic fracture occurs around 10% of the time. Local mass effect can cause a range of symptoms, for example, from posterior expansion into the spinal canal.
Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Giant cell tumor
From Wikibooks, the open-content textbooks collection
Type: Reference Material
Submitted by: admin
Added: Fri Dec 01 2006
Last Modified: Sun Nov 29 2009